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Microcrystalline Cellulose PH102 (CAS 9004-34-6) | USP-NF Excipient for Direct Compression
Order(MOQ) :
500kgProduct Origin :
ChinaColor :
White or almost whiteShipping Port :
Shanghai, ChinaLead Time :
2-3 weeksWeight :
25kgCas No. :
9004-34-6Molecular Formula :
(C₆H₁₀O₅)nAppearance :
White or almost white, fine or granular powder; odorless and tastelessApplication :
Tablet diluent / binder, disintegrant for direct compression
Microcrystalline Cellulose (MCC, CAS 9004-34-6) is a purified, partially depolymerized cellulose obtained by treating fibrous pulp with dilute mineral acid, followed by purification and spray drying. PH102 is a granular, coarser particle-size grade engineered for direct compression, offering excellent flow properties and compactibility without the need for pregranulation.
It is practically insoluble in water, dilute acids, alkali solutions and common organic solvents, and is chemically inert, making it one of the most versatile and widely accepted excipients in oral solid-dosage form manufacturing.
Application Fields
1. Pharmaceutical Oral Solid Dosage Forms
As a diluent and binder for direct-compression tablets and as a capsule filler. It also promotes tablet disintegration, supporting rapid drug release.
2. Nutraceutical & Dietary Supplements
Used as a filler and anti-caking agent in vitamin tablets, effervescent tablets and herbal supplement capsules.
3. Food & Cosmetics
Employed as an anti-caking agent, texturizer and stabilizer in food products, and as an absorbent and texturing agent in powder cosmetics.
Technical Specifications
|
Item |
Specification |
Test Standard / Remarks |
|
Product Name |
Microcrystalline Cellulose PH102 |
Also known as: Cellulose, Microcrystalline |
|
CAS Number |
9004-34-6 |
Key identifier |
|
Molecular Formula |
(C₆H₁₀O₅)n |
n ≈ 220; degree of polymerization ≤ 350 |
|
Appearance |
White or almost white, fine or granular powder |
Odorless, tasteless |
|
Identification |
IR conforms; violet-blue color reaction; DP ≤ 350 |
USP43-NF38 |
|
Granulometry |
Retained on 60 mesh ≤ 8%; passed through 200 mesh ≥ 45% |
Typical 2.7% / 59.6% |
|
pH (10% slurry) |
5.0 – 7.5 |
Typical 6.2 |
|
Loss on Drying |
≤ 7.0% |
Typical 4.1% |
|
Residue on Ignition |
≤ 0.10% |
Typical 0.01% |
|
Water-Soluble Substances |
≤ 0.25% |
Typical 0.13% |
|
Bulk Density |
0.30 – 0.45 g/mL |
Typical 0.39 g/mL |
|
Heavy Metals |
≤ 10 ppm (0.001%) |
Conforms |
|
Microbial Limits |
TAMC ≤ 1000 cfu/g; TYMC ≤ 100 cfu/g; E. coli / Salmonella absent |
Conforms |
|
Solubility |
Insoluble in water, ethanol, ether and dilute acids; slightly soluble in 50% w/w NaOH |
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