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Benzocaine (CAS 94-09-7) | High Purity Local Anesthetic API Manufacturer
Item No :
DetailsOrder(MOQ) :
100kgsProduct Origin :
ChinaColor :
White (crystalline powder); colorless (orthorhombic crystals)Shipping Port :
Shanghai, ChinaLead Time :
2-3 weeksWeight :
25kgCas No. :
94-09-7Molecular Formula :
C₉H₁₁NO₂Appearance :
Colorless orthorhombic crystals or white crystalline powder, odorlessAssay :
98.0% – 102.0% (USP Standard) / 99.0% – 101.0% (BP Standard), compliant with USP/EP/ChP pharmacopoeiaApplication :
A classic ester-type local anesthetic API, widely used in over-the-counter (OTC) topical anesthetic creams, hemorrhoid ointments, oral ulcer lozenges
Benzocaine (Ethyl p-Aminobenzoate, CAS 94-09-7) is a pharmaceutical-grade local anesthetic API, appearing as colorless orthorhombic crystals or white crystalline powder, odorless.
It exerts a local anesthetic effect by blocking nerve impulse transmission in the skin and mucous membranes, effectively relieving pain and itching.
It is widely used in pharmaceutical and personal care products, including topical anesthetic creams, ointments and sprays, wound analgesic preparations, hemorrhoid pain relief products, as well as oral and throat lozenges.
As a professional source manufacturer, we supply high-purity Benzocaine conforming to pharmacopoeia standards such as USP, EP and CP, with stable and consistent bulk supply capacity.
Core Advantages
1. Classic Local Anesthetic API
Long-lasting anesthetic effect: Slowly absorbed upon topical administration, providing prolonged local anesthesia.
High safety profile: Toxicity is only 1/20 to 1/160 of cocaine, making it widely used in over-the-counter (OTC) topical products.
Flexible formulation compatibility: Can be formulated into creams, ointments, gels, sprays, solutions, lozenges and other dosage forms.
2. Global Regulatory Recognition
US FDA: Approved in the OTC Topical Analgesic Monograph (21 CFR Part 346) for topical use at concentrations of 5% – 20%, and for rectal/anal use at 3% – 7.5%.
Chinese Pharmacopoeia (ChP): Officially listed in the Chinese Pharmacopoeia.
European Pharmacopoeia (EP) / British Pharmacopoeia (BP): Complies with European and American pharmacopoeial standards, well accepted in EU and US markets.
3. Wide Range of Applications
Covers various local anesthetic needs, from common insect bites to professional medical procedures.
Suitable for OTC preparations, allowing end products to be sold without a prescription.
Technical Specifications
| Item Typical | Specifications | Test Standard / Remarks |
| Product Name | Benzocaine | Also known as: Ethyl p-Aminobenzoate |
| CAS Number | 94-09-7 | Key Identifier |
| Molecular Formula | C₉H₁₁NO₂ | —— |
| Molecular Weight | 165.19 | —— |
| Appearance | Colorless orthorhombic crystals or white crystalline powder | Odorless |
| Assay (HPLC) | 98.0% – 102.0% (USP Standard) / 99.0% – 101.0% (BP Standard) | Complies with USP/EP/ChP Pharmacopoeia Standards |
| Melting Point | 88 – 92°C | Meets Pharmacopoeia Requirements |
| Solubility | Very slightly soluble in water (approx. 1:2500); freely soluble in ethanol, chloroform, ether; slightly soluble in fatty oils | —— |
| Heavy Metals | Complies with USP/EP Standards | —— |
Key Application
1. Pharmaceutical Topical Preparations
Topical anesthetic creams, ointments & sprays: Used to relieve pain and itching caused by sunburn, minor burns, insect bites, poison ivy/poison oak irritation, scrapes and cuts. Recommended concentration: 5% – 20% (FDA OTC Monograph Part 346).
Wound analgesic preparations: For pain relief in wounds, ulcers and hemorrhoids, providing analgesic and antipruritic effects.
Oral & throat lozenges: Used to relieve sore throat. Not recommended for children under 2 years of age.
2. Personal Care & Medical Devices
Hemorrhoid topical products: Relieves minor discomfort and itching caused by hemorrhoids.
Medical device lubricants: Used as a water-soluble lubricant applied to catheters or device surfaces to reduce insertion discomfort.
Pre-procedural skin anesthesia: For superficial skin numbing prior to minor medical procedures.
FAQ: benzocaine
Q1: What is Benzocaine?
A: Benzocaine (CAS 94-09-7) is a classic ester-type local anesthetic API, appearing as a white crystalline powder. It works by blocking nerve impulse conduction to relieve pain, itching and burning on the skin and mucous membranes.
Q2: What is Benzocaine mainly used for?
A: It is widely used in topical anesthetic creams, gels, sprays, hemorrhoid ointments, oral and throat lozenges, after-sun products, and medical device lubricants.
Q3: What is the typical concentration of Benzocaine in formulations?
A: For topical OTC products, the commonly used concentration is 5% – 20% (per FDA OTC Monograph 21 CFR Part 346). For rectal/anal preparations, it is usually 3% – 7.5%.
Q4: Is Benzocaine safe for external use?
A: When used as directed, Benzocaine is safe and well-tolerated. Its toxicity is much lower than cocaine. It is widely approved for OTC topical products globally.
Q5: Can Benzocaine be used for children?
A: It is not recommended for children under 2 years old unless under professional medical guidance. For older children, use according to the recommended dosage.
Q6: What are the main pharmacopoeia standards for Benzocaine?
A: Our Benzocaine complies with USP, EP, BP and ChP standards, suitable for pharmaceutical and personal care formulations.
Q7: Does Benzocaine have long-lasting effects?
A: Yes. It is slowly absorbed through the skin and provides relatively long-lasting local anesthetic and analgesic effects.
Q8: Can Benzocaine be used in oral products?
A: Yes, it is widely used in throat lozenges and oral ulcer products to relieve mouth and throat pain.
Q9: What dosage forms can Benzocaine be made into?
A: It can be formulated into creams, ointments, gels, sprays, solutions, lozenges, patches and other dosage forms.
Q10: Do you supply bulk Benzocaine?
A: As a source manufacturer, we provide high-purity Benzocaine with stable bulk supply, complete COA and regulatory documents.
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