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Magnesium Stearate (CAS 557-04-0) | USP-NF Tablet Lubricant & Glidant
Order(MOQ) :
500kgProduct Origin :
ChinaColor :
WhiteShipping Port :
Shanghai, ChinaLead Time :
2-3 weeksWeight :
25kgCas No. :
557-04-0Molecular Formula :
C₃₆H₇₀MgO₄ / Mg(C₁₈H₃₅O₂)₂Appearance :
White, very fine, light powder; greasy to touchApplication :
Tablet lubricant, glidant and anti-adherent
Magnesium Stearate (CAS 557-04-0) is the magnesium salt of stearic acid, commercially supplied as a mixture of magnesium stearate and magnesium palmitate. It appears as a white, very fine, light powder that feels greasy to the touch and is practically insoluble in water, ethanol and ether.
As the most widely used lubricant in oral solid-dosage manufacturing, it reduces friction during compression and ejection, prevents sticking to tooling, and improves the flow of granulations into the die. It is also used as a flow aid and anti-caking agent in cosmetics, food and nutraceutical products.
Application Fields
1. Pharmaceutical Tablet & Capsule Manufacturing
Primary use as a lubricant, glidant and anti-adherent in compressed tablets, capsules and powder blends. Typical concentration: 0.25%–2.0% w/w.
2. Nutraceutical & Dietary Supplements
Added to vitamin, mineral and herbal supplement tablets to improve powder flow and prevent sticking during high-speed compression.
3. Cosmetics & Food
Used as a flow aid and anti-caking agent in powdered cosmetics (face powders, eyeshadows) and as an anti-caking/release agent in powdered food products.
Core Advantages
1. High-Performance Tablet Lubricant
At typical use levels of 0.25%–2.0%, magnesium stearate markedly reduces die-wall friction, lowers ejection force and prevents punch sticking, producing clean, uniform tablets with good surface finish.
2. Pharmacopoeia-Grade Quality
Meets USP43-NF38: Mg content 4.0%–5.0% (calc. on dried substance), stearic acid ≥ 40.0%, and stearic + palmitic acids ≥ 90.0%. Heavy metals (Pb, Cd, Ni) are tightly controlled. Batch COA and MSDS provided; third-party inspection supported.
3. Versatile & Well-Accepted
Compatible with the vast majority of active ingredients and excipients. Beyond pharma tablets, it is used in capsule filling, powdered cosmetics, food anti-caking and as a release agent.
Technical Specifications
|
Item |
Specification |
Test Standard / Remarks |
|
Product Name |
Magnesium Stearate |
Magnesium salt of stearic/palmitic acids |
|
CAS Number |
557-04-0 |
EINECS 209-150-3 |
|
Molecular Formula |
C₃₆H₇₀MgO₄ / Mg(C₁₈H₃₅O₂)₂ |
— |
|
Molecular Weight |
591.24 |
— |
|
Appearance |
White, very fine, light powder; greasy to touch |
Slight characteristic odor |
|
Assay (Mg, on dried basis) |
4.0% – 5.0% |
Typical 4.6% |
|
Stearic Acid |
≥ 40.0% |
Typical 42.2% |
|
Stearic Acid + Palmitic Acid |
≥ 90.0% |
Typical 99.5% |
|
Loss on Drying |
≤ 6.0% |
Typical 4.6% |
|
Chloride / Sulphate |
≤ 0.1% / ≤ 1.0% |
Conforms |
|
Heavy Metals |
Pb ≤ 10 ppm; Cd ≤ 3 ppm; Ni ≤ 5 ppm |
Conforms |
|
Specific Surface Area |
~ 5.9 m²/g |
Typical value |
|
Melting Point |
~ 88 °C (softens / decomposes on heating) |
ICSC 1403 |
|
Density |
~ 1.02 g/cm³ |
— |
|
Solubility |
Practically insoluble in water, ethanol and ether; soluble in hot ethanol |
— |
|
Microbial Limits |
TAMC ≤ 1000 CFU/g; TYMC ≤ 500 CFU/g; E. coli / Salmonella absent |
Conforms |
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