EDTA Disodium Salt CAS 6381-92-6 | Bulk Chelating Agent Supplier

• EDTA Disodium Salt (INCI Name: Disodium EDTA, Chemical Name: Ethylenediaminetetraacetic Acid Disodium Salt, CAS 6381-92-6) is a classic hexadentate strong chelating agent that appears as white crystalline powder.
  
  
• It efficiently sequesters metal ions such as Ca²⁺, Fe³⁺ and Mg²⁺ through six coordination bonds, significantly inhibiting oxidation, discoloration and spoilage reactions catalyzed by metal ions.
  
  
• This product is widely used in food processing (color protection and antioxidant), cosmetics (preservative synergist and foam stabilizer), pharmaceutical preparations and industrial water treatment fields.
  
  
• As a professional source manufacturer, we supply high-purity EDTA-2Na in food grade, cosmetic grade and industrial grade with stable and consistent bulk supply capacity for global customers.
  
  

1. Scalable Supply & Cost Advantages

As a professional source manufacturer, we own mature chloroacetic acid synthesis production lines with an annual automated production capacity of over 10,000 tons. This guarantees stable on-time delivery for large bulk orders and enables us to offer highly competitive ex-factory prices.

2. Strict Quality Control & Global Regulatory Compliance

Our products fully comply with international standards including China GB 1886.100-2015 (National Standard for Food Additives), USP (United States Pharmacopeia), EP (European Pharmacopoeia), US FDA and EU Cosmetics Regulation (EC) No 1223/2009.

Each batch is accompanied by a complete Certificate of Analysis (COA) covering all critical safety indicators including assay, pH value, heavy metals (Pb/Fe), chlorides (Cl⁻), sulfates (SO₄²⁻), moisture content and residue on ignition.

3. Multiple Specifications & Professional Technical Support

Grade Options

We offer a comprehensive range of grades to meet diverse industry needs:

Food grade

Cosmetic grade

Pharmaceutical grade (USP)

Industrial grade

High-purity grade (99.99% metal basis)

Packaging Specifications

Available in various packaging forms:

25kg bags (PE inner bag + woven outer bag)

1 ton jumbo bags

Custom packaging available upon request

Technical Support

We provide professional formulation optimization suggestions and application compliance guidance for different application scenarios including food color protection, cosmetic preservation system construction and industrial water treatment processes. 

1. Food Industry: Color Protection, Antioxidation & Preservation

EDTA-2Na plays a critical role in stabilizing color and extending shelf life in food processing:

Edible fungi & vegetable canning: When compounded with color-protecting agents in edible fungi and algae products, it effectively inactivates polyphenol oxidase (PPO) activity, prevents mushroom browning, and maintains the natural white appearance and nutritional quality of products for a long time. Recommended dosage: 0.1 - 0.2 g/kg.

Condiments & sauces: Used in soy sauce, salad dressings, mayonnaise and other products to prevent oxidative off-flavors caused by metal ion catalysis and maintain clear color.

Beverages & canned goods: Acts as an antioxidant and chelating agent in beer, wine and various meat and fruit cans to prevent turbidity, precipitation and oxidative deterioration.

Regulatory reference: According to China GB 2760 Standard for Food Additives, the maximum usage level is 0.075 – 0.2 g/kg depending on different food categories.

2. Cosmetics & Personal Care: Preservative Synergism & Foam Stabilization

EDTA-2Na is an indispensable auxiliary ingredient in high-end skincare and personal care formulations:

Preservative synergist: By binding with trace metal ions in products, it disrupts the growth environment of microorganisms, effectively enhancing the efficacy of the formulation's preservation system and reducing the required dosage of primary preservatives.

Foam stabilizer: Chelates calcium and magnesium ions in hard water in shampoos and body washes, enhancing the foaming ability of surfactants to produce richer, more stable and finer foam.

Antioxidant protection: Prevents discoloration and rancidity caused by metal ion catalysis in creams and serums containing natural oils or vitamin C, extending product shelf life.

Regulatory compliance: Listed in China's Inventory of Used Cosmetic Ingredients.

3. Pharmaceutical & Biotechnology: Pharmaceutical Excipients & Enzyme Inhibitors

Pharmaceutical excipients: Used as a stabilizer in topical creams, eye drops and injections to prevent oxidation or hydrolysis of active pharmaceutical ingredients.

Research & diagnostics: Acts as an inhibitor of nucleases (DNase) and proteases, protecting DNA and RNA from degradation. It is widely used in biopharmaceutical production and molecular biology experimental buffers.

4. Industrial & Environmental Applications: Water Treatment & Processing Aids

Industrial water treatment: Used as a scale inhibitor and cleaning agent for boiler water and cooling circulating water to prevent scaling in metal pipelines.

Textile & papermaking: Serves as an auxiliary agent to remove metal impurities from raw materials, improving bleaching and dyeing effects.

Metal surface cleaning & electroplating: Controls metal ion concentrations in electroplating baths to enhance coating uniformity and adhesion.

Q1: What is EDTA-2Na?

A: EDTA-2Na (INCI Name: Disodium EDTA, Chemical Name: Ethylenediaminetetraacetic Acid Disodium Salt Dihydrate, CAS 6381-92-6, EINECS: 205-358-3) is a classic hexadentate strong chelating agent. Its molecular formula is C₁₀H₁₄N₂Na₂O₈·2H₂O with a molecular weight of 372.24 g/mol. The commercial form is a white crystalline powder with good flowability, readily soluble in water and almost insoluble in ethanol.

Q2: How does EDTA-2Na work as a chelating agent?

A: EDTA-2Na works through a unique six-coordination bond mechanism. Its molecule contains six donor atoms (two nitrogen atoms and four oxygen atoms) that can form stable 1:1 complexes with most divalent and trivalent metal ions such as Ca²⁺, Fe³⁺, Mg²⁺, Cu²⁺ and Zn²⁺.

By sequestering these metal ions, it effectively prevents metal-catalyzed oxidation, discoloration, rancidity and precipitation reactions, making it an indispensable stabilizer in various industries.

Q3: What are the main applications of EDTA-2Na?

A: EDTA-2Na is a versatile ingredient used across four major industries:

Food industry: Color protection agent, antioxidant and preservative in canned foods, condiments, beverages and edible fungi

Cosmetics & personal care: Preservative synergist, foam stabilizer and antioxidant in shampoos, creams, serums and makeup

Pharmaceutical & biotechnology: Pharmaceutical excipient, stabilizer and enzyme inhibitor in injections, eye drops and biological buffers

Industrial applications: Scale inhibitor, cleaning agent and processing aid in water treatment, textile, papermaking and electroplating

Q4: What is the recommended dosage of EDTA-2Na?

A: Dosage varies by application and regulatory requirements:

Food industry: 0.075 - 0.2 g/kg according to China GB 2760; 0.1 - 0.2 g/kg for edible fungi canning

Cosmetics: 0.05% - 0.2% for most formulations; up to 0.5% in rinse-off products

Industrial water treatment: 5 - 50 mg/L depending on water hardness

Pharmaceuticals: 0.01% - 0.5% as a stabilizer

Q5: Is EDTA-2Na safe for use in food and cosmetics?

A: Yes, EDTA-2Na has an excellent safety profile when used within recommended concentrations:

Global regulatory approval: Approved by US FDA, EU EFSA, and listed in China's GB 2760 and Inventory of Used Cosmetic Ingredients

CIR Safety Assessment: The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Disodium EDTA is safe for use in cosmetics at concentrations up to 2%

Low toxicity: It has extremely low acute toxicity, is not absorbed through the skin, and is rapidly excreted from the body

Q6: What grades of EDTA-2Na do you offer?

A: As a professional source manufacturer, we provide a comprehensive range of grades:

Food grade: ≥98.5% purity, meets GB 1886.100-2015 standard

Cosmetic grade: ≥99.0% purity, suitable for personal care products

Pharmaceutical grade (USP/EP): ≥99.0% purity, meets United States Pharmacopeia and European Pharmacopoeia standards

Industrial grade: ≥99.0% purity, for water treatment and industrial applications

High-purity grade: 99.99% - 99.999% metal basis, for electronic and semiconductor applications

Q7: What is the formulation compatibility of EDTA-2Na?

A: EDTA-2Na exhibits excellent formulation compatibility:

pH stability: Stable in formulations with pH 4.0 - 10.0

Temperature stability: Stable up to 120°C, suitable for most high-temperature processing

Ingredient compatibility: Fully compatible with anionic, cationic and nonionic surfactants, preservatives, emulsifiers and most active ingredients

Synergistic effects: Works exceptionally well with parabens, phenoxyethanol and other preservatives to enhance preservation efficacy

Q8: What is the difference between EDTA-2Na and other EDTA salts?

A: The main differences lie in solubility and pH characteristics:

EDTA-2Na: Solubility ~11 g/100mL water at 25°C, pH 4.0-5.0 (1% solution), most widely used general-purpose chelating agent

EDTA-4Na: Higher solubility (~40 g/100mL), pH ~10.5, suitable for alkaline formulations

EDTA Acid: Very low solubility, used in specialty applications requiring low pH