99.5% Pure Menthol Crystals | Bulk Supply | Factory Price

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1. Dual Supply of Natural & Synthetic Menthol

Menthol crystals are mainly divided into two types: natural L-Menthol (levomenthol) and synthetic DL-Menthol (racemic menthol). Natural menthol is refined via freeze crystallization and separation from natural peppermint oil, with levorotatory optical rotation. Synthetic menthol is produced via catalytic hydrogenation of chemical raw materials such as eucalyptus oil or thymol. Both meet multi-industry requirements in purity and efficacy: natural menthol delivers purer aroma, while synthetic menthol offers higher cost performance. Both can reach pharmaceutical grade and food grade standards.

2. Global Regulatory Compliance & Reference Standards

Pharmaceutical/excipients: Compliant with USP/EP/BP/JP/ChP pharmacopoeia standards, can be used as active pharmaceutical ingredient and excipient for oral and topical preparations

Cosmetics: Safety assessed by CIR, listed in China's Used Cosmetic Ingredients Directory

Food flavor: US FDA GRAS (FEMA No. 2665), compliant with China GB 2760 national standard

3. Stable Market Value

Global demand for menthol is huge with annual trading volume growing continuously. It is one of the largest traded synthetic flavor products, with stable and sustainable market demand.

4. Stable Physicochemical & Processing Properties

High melting point: Natural L-Menthol melting point 41-45°C, synthetic menthol melting point 31-35°C. High melting point prevents accidental melting or caking during high-temperature processing

Thermal stability: Chemically stable under conventional processing conditions (50-80°C melting)

Volatility: Slowly sublimes at room temperature with natural diffusivity, suitable for aromatherapy and air fresheners

Compatibility: Readily soluble in ethanol, miscible with various solvents and fragrance raw materials, can be uniformly dispersed in water-based products via process adjustment

1. Pharmaceutical Preparations (Core Application)

Menthol crystal is a key raw material in the pharmaceutical industry, with multiple functions including cooling, analgesic, antipruritic, anti-inflammatory and carminative effects, widely used in oral and topical pharmaceutical preparations:

Oral preparations: Flavoring and cooling agent for cough syrups, throat lozenges, relieves sore throat and cough symptoms, alleviates cold and upper respiratory tract discomfort

Topical preparations: Active ingredient for pain relief ointments, analgesic liniments, cooling balms, relieves mild muscle pain and joint discomfort

Nasal preparations: Cooling active ingredient for nasal inhalers and nasal sprays, helps relieve nasal congestion

Recommended dosage: 1% – 10% in topical ointments; 0.05% – 0.5% in cough syrups; 0.1% – 0.5% in oral sprays

Recommended combination: Synergistic analgesic and cooling system when combined with camphor, methyl salicylate (wintergreen oil) and eucalyptus oil

Regulatory compliance: Compliant with USP, EP, BP, JP pharmacopoeia standards, approved as pharmaceutical excipient and active ingredient

2. Oral Care & Personal Care Products

Oral care is the largest application field for menthol, accounting for over 25% of total consumption:

Toothpaste & mouthwash: Core flavoring and breath freshening ingredient, delivers long-lasting cooling sensation. Recommended dosage: 0.1% – 0.5%

Oral breath spray: Acts directly on oral mucosa, provides instant cooling sensation and fresh breath. Recommended dosage: 0.5% – 8%

Skincare & personal care: Added to creams, facial cleansers, toners, shampoos and body washes for cooling sensation and mint aroma. Recommended dosage: 0.1% – 1%

3. Food, Beverage & Confectionery

Menthol crystal is a classic flavoring and cooling agent in the food industry, with high safety profile, listed as FDA GRAS (Generally Recognized As Safe) substance, FEMA No. 2665:

Candy & chewing gum: Used in hard candies, mints, compressed candies and chewing gums, delivers strong cooling sensation and long-lasting mint flavor

Beverages & frozen products: Added to carbonated drinks, sports drinks, ice creams and smoothies, enhances cooling experience and oral freshness

Chocolate & bakery: Used in mint chocolate, mint pastries and sugar-free candies

Recommended dosage: 0.05% – 0.1% in candies; 0.1% – 0.3% in chewing gum; 0.002% – 0.01% in beverages

Combination: Can be blended with peppermint oil, spearmint oil and vanillin for enhanced flavor

4. Household Chemicals & Tobacco Industry

Air fresheners & scented candles: Core component of fragrance formulations

Cigarette filters: Added for cooling sensation (menthol cigarettes)

Industrial fresheners & deodorants: Applied in public spaces and household products

Q1: What is Menthol Crystal, and what are its standard CAS numbers?

A: Menthol Crystal (also called Menthol) is a natural monoterpene alcohol compound with strong mint aroma and cooling sensation, appearing as colorless transparent needle crystals. It has two main commercial types with corresponding CAS numbers: L-Menthol (natural levomenthol, CAS 2216-51-5) and DL-Menthol (synthetic racemic menthol, CAS 89-78-1 / 1490-04-6). It is the most widely used cooling agent globally.

Q2: What is the difference between L-Menthol and DL-Menthol?

A: The core differences between the two types are:

Source: L-Menthol is natural, refined from peppermint oil via freeze crystallization; DL-Menthol is synthetic, produced via catalytic hydrogenation of chemical raw materials

Aroma: L-Menthol has purer, more natural mint aroma; DL-Menthol has slightly stronger cooling intensity but less pure aroma

Melting point: L-Menthol 41-45°C; DL-Menthol 31-35°C

Cost: DL-Menthol offers higher cost performance for large volume use; L-Menthol is preferred for high-end food and pharmaceutical products

Both can reach food grade and pharmaceutical grade purity standards.

Q3: How does Menthol produce cooling sensation and analgesic effect?

A: Menthol exerts its effects via two targeted mechanisms:

Cooling sensation: Binds to TRPM8 cold receptors on the skin and mucosa, producing a long-lasting cooling feeling without actual temperature change

Analgesic effect: Inhibits TTX-R sodium ion channels and calcium ion channels, delivering both central and peripheral dual analgesic effect. A 2025 clinical study confirmed its effectiveness in relieving both inflammatory pain and neuropathic pain.

Q4: What is the recommended usage level of Menthol Crystal in formulations?

A: The standard recommended dosage varies by application:

Pharmaceuticals: 1% – 10% in topical ointments; 0.05% – 0.5% in cough syrups

Oral care: 0.1% – 0.5% in toothpaste/mouthwash; 0.5% – 8% in oral sprays

Food & confectionery: 0.05% – 0.1% in candies; 0.1% – 0.3% in chewing gum; 0.002% – 0.01% in beverages

Skincare & personal care: 0.1% – 1% in creams, shampoos and body washes

Q5: Is Menthol Crystal compliant with global regulatory standards?

A: Yes, Menthol Crystal has full global regulatory approval:

Pharmaceutical: Compliant with USP, EP, BP, JP, ChP pharmacopoeia standards, approved as API and excipient

Cosmetics: CIR safety assessed, listed in global cosmetic ingredient directories

Food: US FDA GRAS (Generally Recognized As Safe, FEMA No. 2665), compliant with GB 2760 and EU food additive standards

Q6: What is the latest clinical research on Menthol's efficacy?

A: A 2025 systematic review on menthol for pain management confirmed:

It effectively relieves both inflammatory pain and neuropathic pain, including migraine and muscle soreness

It has significant antipruritic effect for skin irritation

It shows antibacterial activity against common oral bacteria, supporting its wide use in oral care products

Q7: In which products and industries is Menthol Crystal commonly applied?

A: Menthol Crystal is widely used across 5 major industries:

Pharmaceuticals: Topical ointments, cough drops, nasal inhalers, pain relief liniments

Oral care: Toothpaste, mouthwash, breath sprays, throat lozenges

Food & beverage: Candies, chewing gum, mints, carbonated drinks, ice cream

Personal care: Skincare creams, shampoos, body washes, after-sun products

Tobacco & household: Menthol cigarettes, air fresheners, scented candles, deodorants

Q8: What are the key quality specifications for premium Menthol Crystal?

A: High-quality food/pharmaceutical grade Menthol Crystal meets the following core specifications:

Purity (GC): ≥ 99% (≥99.5% customizable)

Melting point: 41-45°C (L-Menthol) / 31-35°C (DL-Menthol)

Heavy metals: ≤ 10 ppm

Loss on drying: ≤ 1.0%

Specific rotation (L-Menthol): -45° – -51°

Q9: Is Menthol Crystal water soluble?

A: Menthol Crystal is slightly soluble in water, but readily soluble in ethanol, chloroform, ether and oils. It can be uniformly dispersed in water-based formulations via solubilizers or process adjustment, and can be directly added to the oil phase of emulsion products during the heating phase.

Q10: Is Menthol Crystal safe for food and pharmaceutical use?

A: Yes, high-purity refined Menthol Crystal has an excellent safety profile. It has been used globally for over 100 years, with FDA GRAS status for food use and full pharmacopoeia approval for pharmaceutical use. When used within the recommended dosage range, it is safe for all approved applications.

Q11: What ingredients can Menthol be combined with for synergistic effect?

A: Menthol delivers excellent synergistic effects when combined with:

Analgesic formulations: Camphor, methyl salicylate (wintergreen oil), eucalyptus oil for enhanced pain relief

Oral care: Peppermint oil, spearmint oil for enhanced freshness and antibacterial effect

Cooling formulations: WS-23, WS-3 for longer-lasting, non-irritating cooling sensation